Principal investigator

Caroline Curtin

Principal Investigator

Bio-nano interactions · Biomaterials · Gene delivery · Bone and joint repair

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About

Research profile

Caroline Curtin develops gene-activated scaffolds for musculoskeletal regeneration and uses engineered three-dimensional tissue models to investigate cancers and targeted therapies.

Expertise

Research interests

01Bio-nano interactions

02Biomaterials

03Gene delivery

04Bone and joint repair

05Drug delivery

06Nanomedicine

07Stem-cell biology

08Tissue engineering

09Cancer models

10Therapeutics

Lab members

Caroline’s research team

Browse PI groups

PhD researchers

PhD Researcher

Harini Ganesh

Harini Ganesh is a PhD researcher in Caroline Curtin’s research group at TERG, RCSI.

hariniganesh@rcsi.com View profile

PhD Researcher

Na Zhao

Na Zhao is a PhD researcher in Caroline Curtin’s research group at TERG, RCSI.

nazhao23@rcsi.com View profile

Selected outputs

Highlighted publications

All publications by this PI

2025Biofabrication

Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects.

Genoud KJ, Sadowska JM, Power RN, Costard LS, Ryan EJ, Matherson AR, Gonzalez-Vazquez AG, Lemoine M, Eichholz K, Pitacco P, Chen G, Cavanagh B, Garcia O, Murphy CM, Curtin CM, Kelly DJ, O'Brien FJ

Biofabrication and 3D printing Antimicrobial and immunomodulatory materials Bone, cartilage, joint repair and PTOA Biomaterial scaffolds

DOI Article

2024Advanced materials (Deerfield Beach, Fla.)

A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles.

Sadowska JM, Power RN, Genoud KJ, Matheson A, González-Vázquez A, Costard L, Eichholz K, Pitacco P, Hallegouet T, Chen G, Curtin CM, Murphy CM, Cavanagh B, Zhang H, Kelly DJ, Boccaccini AR, O'Brien FJ

Gene-activated materials Antimicrobial and immunomodulatory materials Bone, cartilage, joint repair and PTOA Targeted therapeutic delivery Biomaterial scaffolds

DOI Article

2023BiofabricationFeatured

An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects

Donagh G. O’Shea, Tom Hodgkinson, Caroline M. Curtin and Fergal J. O’Brien

Hydrogels Biofabrication and 3D printing Bone, cartilage, joint repair and PTOA

DOI Article

2023Methods in Molecular Biology

Assessment of Cell Cytotoxicity in 3D Biomaterial Scaffolds Following miRNA Transfection

Elizabeth Sainsbury, Lara Costard, Fergal J. O’Brien and Caroline M. Curtin

Biomaterial scaffolds Gene-activated materials Advanced disease models

DOI Article

2023Acta biomaterialia

Dual scaffold delivery of miR-210 mimic and miR-16 inhibitor enhances angiogenesis and osteogenesis to accelerate bone healing.

Castaño IM, Raftery RM, Chen G, Cavanagh B, Quinn B, Duffy GP, Curtin CM, O'Brien FJ

Bone, cartilage, joint repair and PTOA Targeted therapeutic delivery Biomaterial scaffolds

DOI Article

2022Nature reviews. Rheumatology

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.

Hodgkinson T, Kelly DC, Curtin CM, O'Brien FJ

Bone, cartilage, joint repair and PTOA

DOI Article

Industry & translation

Turning research into impact.

TERG works with academic, clinical and industry partners to move biomaterials, devices and regenerative technologies towards patient benefit.

Industry, spin-outs and collaboration

Contact

Start a conversation.

For research, collaboration and supervision enquiries, email carolinecurtin@rcsi.com.

Lab contact details