Clinical applications
Bone, cartilage, joint repair and PTOA
Regenerative and drug-delivery strategies for bone defects, cartilage damage, osteoarthritis and post-traumatic osteoarthritis (PTOA).
Overview
About this research
Regenerative and drug-delivery strategies for bone defects, cartilage damage, osteoarthritis and post-traumatic osteoarthritis (PTOA).
People
Research team
Director of TERG · Professor of Bioengineering and Regenerative Medicine · Principal Investigator
Fergal O’Brien
Biomaterials · Tissue engineering · Regenerative medicine
Senior Lecturer · Principal Investigator
Ciara Murphy
Biomaterials · Bioengineering · Bioinorganic ions
Outputs
Related publications
The Design and Development of an Injectable Thermoresponsive Hydrogel for Controlled Simvastatin Release in Bone Repair Applications
Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects.
Magnesium Ion-Mediated Regulation of Osteogenesis and Osteoclastogenesis in 2D Culture and 3D Collagen/Nano-Hydroxyapatite Scaffolds for Enhanced Bone Repair.
A biomimetic reinforced type I/II collagen and hyaluronic acid scaffold in combination with a chondral biomaterial fixation technique for large articular cartilage defect repair: A pilot pre-clinical study.
A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair
Mobilizing Endogenous Progenitor Cells Using pSDF1α-Activated Scaffolds Accelerates Angiogenesis and Bone Repair in Critical-Sized Bone Defects
A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles.
An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects
Dual scaffold delivery of miR-210 mimic and miR-16 inhibitor enhances angiogenesis and osteogenesis to accelerate bone healing.
Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms.
Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.
The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis.
Impact of Fluid Flow Shear Stress on Osteoblast Differentiation and Cross-Talk with Articular Chondrocytes.
Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation.
Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering.
The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells.
Rapid bone repair with the recruitment of CD206(+)M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells.
Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds.
Collaborate
Bring a problem worth solving.
We welcome conversations with academic, clinical and industry partners whose expertise can create a stronger route to impact.
Contact the lab