Principal investigator

Adrian Dervan

Principal Investigator

Bioinformatics · Genetic analysis · Gene delivery · Genomics

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About

Research profile

Adrian Dervan’s research connects neuroscience, genomics and gene delivery with stem-cell biology and the study of neural injury and repair.

Expertise

Research interests

01Bioinformatics

02Genetic analysis

03Gene delivery

04Genomics

05Human genetics

06Neuroscience

07Stem-cell biology

Lab members

Adrian’s research team

Browse PI groups

No lab members are currently listed.

Current work

Research projects

Research areas

Electroactive biomaterials and stimulation

Graphene, MXene and conductive-polymer systems that deliver or direct electrical stimulation for regenerative and neurological applications.

3 associated researchers

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Clinical applications

Spinal cord, peripheral nerve and neural repair

Biomimetic scaffolds, gene therapeutics and electroconductive implants for neurotrauma repair and neurological disease.

4 associated researchers

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Selected outputs

Highlighted publications

All publications by this PI

2026Biomaterials advancesFeatured

Laminin 1 enhances the angiogenic and neurogenic potential of collagen-based scaffolds for complex wound healing applications.

McGrath M, Palomeque-Chávez JC, O'Connor C, Maughan J, Dervan A, Browne S, O'Brien FJ

Spinal cord, peripheral nerve and neural repair Skin and wound healing Biomaterial scaffolds

DOI Article

2026Bioactive materials

Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing.

Palomeque Chávez JC, Dobricic M, McGrath M, O'Connor C, McGuire T, Maughan J, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

Gene-activated materials Antimicrobial and immunomodulatory materials Spinal cord, peripheral nerve and neural repair Skin and wound healing Biomaterial scaffolds

DOI Article

2025Advanced ScienceFeatured

3D-Printing of Electroconductive MXene-Based Micro-Meshes in a Biomimetic Hyaluronic Acid-Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Ian Woods, Dahnan Spurling, S. Sunil, Anne Marie O’Callaghan, Jack Maughan, Javier Gutierrez Gonzalez, Tara K. McGuire, Liam M. Leahy, Adrian Dervan, Valeria Nicolosi and Fergal J. O’Brien

Hydrogels Biofabrication and 3D printing Electroactive biomaterials and stimulation Spinal cord, peripheral nerve and neural repair

DOI

2025Advanced Healthcare MaterialsFeatured

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix-Dependent Manner for Spinal Cord Repair Applications

Cian O’Connor, Ian Woods, Sarah F. McComish, Sean Kerr, Matthew McGrath, Juan Carlos Palomeque Chávez, Jack Maughan, Tara McGuire, Maeve A. Caldwell, Adrian Dervan and Fergal J. O’Brien

Biomaterial scaffolds Antimicrobial and immunomodulatory materials Spinal cord, peripheral nerve and neural repair

DOI Article

2025Biomaterials science

Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications.

Palomeque Chávez JC, McGrath M, O'Connor C, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

Spinal cord, peripheral nerve and neural repair Skin and wound healing Biomaterial scaffolds

DOI Article

2025Journal of anatomy

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell- and nano-scale process extension for neural repair applications.

O'Connor C, Mullally RE, McComish SF, O'Sullivan J, Woods I, Schoen I, Garre M, Caldwell MA, Dervan A, O'Brien FJ

Spinal cord, peripheral nerve and neural repair Biomaterial scaffolds

DOI Article

Industry & translation

Turning research into impact.

TERG works with academic, clinical and industry partners to move biomaterials, devices and regenerative technologies towards patient benefit.

Industry, spin-outs and collaboration

Contact

Start a conversation.

For research, collaboration and supervision enquiries, email adriandervan@rcsi.com.

Lab contact details