Clinical applications

Skin and wound healing

Hydrogels and multilayered biomaterials that promote angiogenesis, control inflammation and infection, and support chronic-wound repair.

Overview

About this research

Hydrogels and multilayered biomaterials that promote angiogenesis, control inflammation and infection, and support chronic-wound repair.

People

Research team

Principal Investigator

Shane Browne

Angiogenesis · Biomaterials · Gene delivery

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Director of TERG · Professor of Bioengineering and Regenerative Medicine · Principal Investigator

Fergal O’Brien

Biomaterials · Tissue engineering · Regenerative medicine

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Head of Department · Principal Investigator

Garry Duffy

Translational medicine · Medical devices · Chronic wound technologies

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Outputs

Related publications

2026Biomaterials advancesFeatured

Laminin 1 enhances the angiogenic and neurogenic potential of collagen-based scaffolds for complex wound healing applications.

McGrath M, Palomeque-Chávez JC, O'Connor C, Maughan J, Dervan A, Browne S, O'Brien FJ

Spinal cord, peripheral nerve and neural repair Skin and wound healing Biomaterial scaffolds

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2026Bioactive materials

Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing.

Palomeque Chávez JC, Dobricic M, McGrath M, O'Connor C, McGuire T, Maughan J, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

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2025International Wound Journal

Understanding the Impact of Ostomy Dejecta Constituents on Peristomal Skin Health and Models for Its Characterisation

Mirella A. Ejiugwo, Julie V. Gawenda, Abram D. Janis, Deborah A. McNamara, Sinéad T. O’Donnell and Shane Browne

Skin and wound healing Advanced disease models

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2025Biomaterials science

Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications.

Palomeque Chávez JC, McGrath M, O'Connor C, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

Spinal cord, peripheral nerve and neural repair Skin and wound healing Biomaterial scaffolds

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2024Molecular biology reports

Extracellular matrix-inspired biomaterials for wound healing.

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Skin and wound healing Biomaterial scaffolds

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2023ACS Applied Materials & Interfaces

A Biomimetic, Bilayered Antimicrobial Collagen-Based Scaffold for Enhanced Healing of Complex Wound Conditions

Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne and Fergal J. O’Brien

Biomaterial scaffolds Antimicrobial and immunomodulatory materials Skin and wound healing

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2021Polymers

3D-Printed Gelatin Methacrylate Scaffolds with Controlled Architecture and Stiffness Modulate the Fibroblast Phenotype towards Dermal Regeneration.

R Ibañez RI, do Amaral RJFC, Reis RL, Marques AP, Murphy CM, O'Brien FJ

Hydrogels Biofabrication and 3D printing Skin and wound healing Biomaterial scaffolds

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