Research that moves the field forward.

Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing.

Palomeque Chávez JC, Dobricic M, McGrath M, O'Connor C, McGuire T, Maughan J, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

Advances in tissue engineering strategies for periodontal and endodontic regeneration: Current therapies and future trends for disease treatment and tissue repair in the oral cavity.

Sheehy EJ, Coffey N, Quigley RM, Duncan HF, Kennedy OD, O Brien FJ

Development of a PTEN-siRNA activated scaffold to promote axonal regrowth following spinal cord injury.

McGuire TK, Stasiewicz M, O'Connor C, Woods I, Maughan J, Dobricic M, Brunetti G, Dixon JE, Dervan AG, O'Brien FJ

Patient-specific investigation into plaque rupture risk due to catheter tracking during TAVR

David G. Symes, Laoise M. McNamara and Claire Conway

Patient-specific computational modelling was used to investigate plaque injury risk during transcatheter aortic valve procedures.

Understanding the Impact of Ostomy Dejecta Constituents on Peristomal Skin Health and Models for Its Characterisation

Mirella A. Ejiugwo, Julie V. Gawenda, Abram D. Janis, Deborah A. McNamara, Sinéad T. O’Donnell and Shane Browne

This review examines drivers of peristomal skin complications and models for testing preventive interventions.

Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications.

Palomeque Chávez JC, McGrath M, O'Connor C, Dervan A, Dixon JE, Kearney CJ, Browne S, O'Brien FJ

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell- and nano-scale process extension for neural repair applications.

O'Connor C, Mullally RE, McComish SF, O'Sullivan J, Woods I, Schoen I, Garre M, Caldwell MA, Dervan A, O'Brien FJ

Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects.

Genoud KJ, Sadowska JM, Power RN, Costard LS, Ryan EJ, Matherson AR, Gonzalez-Vazquez AG, Lemoine M, Eichholz K, Pitacco P, Chen G, Cavanagh B, Garcia O, Murphy CM, Curtin CM, Kelly DJ, O'Brien FJ

Magnesium Ion-Mediated Regulation of Osteogenesis and Osteoclastogenesis in 2D Culture and 3D Collagen/Nano-Hydroxyapatite Scaffolds for Enhanced Bone Repair.

Paiva SS, Ferreira A, Pakenham E, Kaur K, Cavanagh B, O'Brien FJ, Murphy CM

A biomimetic reinforced type I/II collagen and hyaluronic acid scaffold in combination with a chondral biomaterial fixation technique for large articular cartilage defect repair: A pilot pre-clinical study.

Intini C, Joyce M, Uberti M, Labberté MC, Brunetti G, Hackett B, Hodgkinson T, O'Byrne JM, Brama PAJ, O'Brien FJ

Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations.

Petit N, Chang YJ, Lobianco FA, Hodgkinson T, Browne S

Mobilizing Endogenous Progenitor Cells Using pSDF1α-Activated Scaffolds Accelerates Angiogenesis and Bone Repair in Critical-Sized Bone Defects

Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, David P. Walsh, Gang Chen, Ashang L. Laiva, Michael B. Keogh and Fergal J. O’Brien

A gene-activated scaffold recruits endogenous progenitor cells to accelerate blood-vessel formation and repair critical-sized bone defects.

Computational Investigation of Vessel Injury Due to Catheter Tracking During Transcatheter Aortic Valve Replacement

David G. Symes, Laoise M. McNamara and Claire Conway

Computational models were used to investigate vessel-wall injury caused by catheter tracking during TAVR.

In vivo cisplatin-resistant neuroblastoma metastatic model reveals TNFRSF4 as an independent prognostic factor of survival in neuroblastoma

Catherine Murphy, Laura Devis-Jauregui, Ronja Struck, Ariadna Boloix, Ciara Gallagher, Cian Gavin, Federica Cottone, Aroa Soriano Fernandez, Stephen Madden, Josep Roma, Miguel F. Segura and Olga Piskareva

A cisplatin-resistant metastatic neuroblastoma model identified TNFRSF4 as a potential independent prognostic factor.

A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles.

Sadowska JM, Power RN, Genoud KJ, Matheson A, González-Vázquez A, Costard L, Eichholz K, Pitacco P, Hallegouet T, Chen G, Curtin CM, Murphy CM, Cavanagh B, Zhang H, Kelly DJ, Boccaccini AR, O'Brien FJ

Biosensors with left ventricular assist devices.

Abbassy M, Ali MZ, Sharma RM, Irani YP, Dahlan A, Azhar M, Aslam N, Hasan B, Hameed A

Extracellular matrix-inspired biomaterials for wound healing.

Hosty L, Heatherington T, Quondamatteo F, Browne S

A Biomimetic, Bilayered Antimicrobial Collagen-Based Scaffold for Enhanced Healing of Complex Wound Conditions

Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne and Fergal J. O’Brien

A bilayered collagen scaffold combines biomimetic structure with antimicrobial functionality for complex wound healing.

Assessment of Cell Cytotoxicity in 3D Biomaterial Scaffolds Following miRNA Transfection

Elizabeth Sainsbury, Lara Costard, Fergal J. O’Brien and Caroline M. Curtin

A reproducible method is described for assessing cytotoxicity following microRNA transfection in three-dimensional biomaterial scaffolds.

Dual scaffold delivery of miR-210 mimic and miR-16 inhibitor enhances angiogenesis and osteogenesis to accelerate bone healing.

Castaño IM, Raftery RM, Chen G, Cavanagh B, Quinn B, Duffy GP, Curtin CM, O'Brien FJ

The Manufacture and Characterization of Biomimetic, Biomaterial-Based Scaffolds for Studying Physicochemical Interactions of Neural Cells in 3D Environments.

O'Connor C, Woods I, Hibbitts A, Dervan A, O'Brien FJ

A European update on transcatheter aortic valve implantation (TAVI) in the COVID era.

Antony I, Mehari Abraha H, Hameed A, Conway C

Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy.

Malone G, Abdelsayed G, Bligh F, Al Qattan F, Syed S, Varatharajullu P, Msellati A, Mwipatayi D, Azhar M, Malone A, Fatimi SH, Conway C, Hameed A

Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms.

Sadowska JM, Ziminska M, Ferreira C, Matheson A, Balouch A, Bogle J, Wojda S, Redmond J, Elkashif A, Dunne N, McCarthy HO, Donahue S, O'Brien FJ

Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting.

Kaur K, Sannoufi R, Butler JS, Murphy CM

Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment.

Monaghan MG, Borah R, Thomsen C, Browne S

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.

Hodgkinson T, Kelly DC, Curtin CM, O'Brien FJ

Biomimetic Scaffolds for Spinal Cord Applications Exhibit Stiffness-Dependent Immunomodulatory and Neurotrophic Characteristics.

Woods I, O'Connor C, Frugoli L, Kerr S, Gutierrez Gonzalez J, Stasiewicz M, McGuire T, Cavanagh B, Hibbitts A, Dervan A, O'Brien FJ

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis.

Hodgkinson T, Amado IN, O'Brien FJ, Kennedy OD

Impact of Fluid Flow Shear Stress on Osteoblast Differentiation and Cross-Talk with Articular Chondrocytes.

Hinton PV, Genoud KJ, Early JO, O'Brien FJ, Kennedy OD

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation.

Intini C, Hodgkinson T, Casey SM, Gleeson JP, O'Brien FJ

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering.

O'Shea DG, Curtin CM, O'Brien FJ

Diuretic therapy in congestive heart failure.

Kennelly P, Sapkota R, Azhar M, Cheema FH, Conway C, Hameed A

Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction.

Rosalia L, Ozturk C, Shoar S, Fan Y, Malone G, Cheema FH, Conway C, Byrne RA, Duffy GP, Malone A, Roche ET, Hameed A

Towards the use of localised delivery strategies to counteract cancer therapy-induced cardiotoxicities.

Monahan DS, Almas T, Wyile R, Cheema FH, Duffy GP, Hameed A

Influences of the 3D microenvironment on cancer cell behaviour and treatment responsiveness: A recent update on lung, breast and prostate cancer models.

Costard LS, Hosn RR, Ramanayake H, O'Brien FJ, Curtin CM

Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity.

Monahan DS, Flaherty E, Hameed A, Duffy GP

3D-Printed Gelatin Methacrylate Scaffolds with Controlled Architecture and Stiffness Modulate the Fibroblast Phenotype towards Dermal Regeneration.

R Ibañez RI, do Amaral RJFC, Reis RL, Marques AP, Murphy CM, O'Brien FJ

Three-dimensional In Vitro Biomimetic Model of Neuroblastoma using Collagen-based Scaffolds.

Gallagher C, Murphy C, O'Brien FJ, Piskareva O

The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells.

Coughlin TR, Sana A, Voss K, Gadi A, Basu-Roy U, Curtin CM, Mansukhani A, Kennedy OD

Rapid bone repair with the recruitment of CD206(+)M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells.

Castaño IM, Raftery RM, Chen G, Cavanagh B, Quinn B, Duffy GP, O'Brien FJ, Curtin CM

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications.

Costard LS, Kelly DC, Power RN, Hobbs C, Jaskaniec S, Nicolosi V, Cavanagh BL, Curtin CM, O'Brien FJ

Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions.

Gallagher LB, Dolan EB, O'Sullivan J, Levey R, Cavanagh BL, Kovarova L, Pravda M, Velebny V, Farrell T, O'Brien FJ, Duffy GP

A Context-Dependent Role for MiR-124-3p on Cell Phenotype, Viability and Chemosensitivity in Neuroblastoma in vitro.

Nolan JC, Salvucci M, Carberry S, Barat A, Segura MF, Fenn J, Prehn JHM, Stallings RL, Piskareva O

Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds.

Sridharan R, Genoud KJ, Kelly DJ, O'Brien FJ